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While the trials were negative clinically, presenters and discussants noted biomarker changes consistent with reduced neuroinflammation (e.g., decreases in highsensitivity CRP) and other Alzheimersrelated signalsmodest but statistically significant effects that did not yield measurable cognitive benefit

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Two oligopeptides (Asn-Met-Cys-Ser and Asn-Cys-Pro-Pro) were associated with proteinuria severity, with AUC values of 0.8857 and 0.9963, respectively ( 4.5.3 Methodological considerations in biomarker research 4.5.3.1 Evidence strength assessment and study limitations Current metabolomic investigations predominantly employ cross-sectional designs or case-control methodologies, which harbor intrinsic deficiencies in causal inference