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Metformin also mimics pharmacologic preconditioning (e.g., sevoflurane) by activating Akt and upregulating anti-apoptotic proteins such as Bcl-xL (Rozier et al., 2021)

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Novo Nordisks Response to JAMA Study and Allegations In an emailed statement, Wegovy manufacturer Novo Nordisk countered that there were several limitations of the JAMA study design, which was not a randomized controlled trial, as reported by Reuters