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P53 phosphorylation at Ser15 enhances the affinity of both FOXO4 and FOXO4-DRI for p53 TAD2 explaining the preferential engagement of FOXO4-DRI with the hyperphosphorylated p53 characteristic of senescent cells

ADH5 was reported to operate preventing FA toxicity in bacteria, mice, and humans, suggesting a widely conserved function of this enzyme 8