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Low stomach acid can lead to poor protein digestion, bloating, reflux, feeling excessively full after meals, nutrient deficiencies (like B12, iron and zinc) and increase the risk of infections in the gut due to reduced defence against harmful microbes.

doi:10.1016/j.jdiacomp.2022.108255 8

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Hydrogen bonding between the sulphonyl moiety of the inhibitor and the hydroxyl group of an evolutionary conserved tyrosine residue, Tyr7, provides the first direct structural evidence for a catalytic protein group in glutathione S-transferases that is involved in the activation of the substrate glutathione