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Direct substrate supplementation by NMN efficiently boosts NAD+ via salvage pathway saturation

By relying on independent verification, we prioritize consistency, accuracy, and accountability at every stage

With the right investigation, a clear picture of whats driving it, and a systematic approach to addressing those drivers in the right order, the gut lining can heal and the broader effects of that healing, on immunity, inflammation, energy, skin, and mood, can be profound

In the Phase 2 obesity trial published in NEJM in 2023, retatrutide at the 12 mg weekly dose produced a mean placebo-adjusted body weight reduction of 22.1 percentage points (22.1% (24.2% arm) mean absolute reduction on the retatrutide arm) at 48 weeks (Jastreboff et al., NEJM, 2023)