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As expected, the control miRNA, miR-21-5p, required Drosha for its production and its levels were dramatically diminished in the Drosha-deficient cells (Fig 2A)

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To construct plasmids for expression of ser-1 in C

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2.13.1.2 E693del (Osaka) mutation The APP E693-Tg (Osaka) mouse model, which carries the Osaka mutation (APP695) under the control of the mouse prion promoter, expressed comparable levels of mutant human APP and endogenous mouse APP

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