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Human trials with Rg1 show ~20% longer time-to-exhaustion, faster post-exercise glycogen resynthesis, a rise in citrate synthase (CS) activity, and a shift toward an anti-inflammatory profile in exercised muscle tissue

Because of their opposite functions on food intake and metabolic targets (Engelstoft & Schwartz, 2016), both hormones have gained traction as pharmacological targets for treatment of metabolic (i.e., obesity and type 2 diabetes (T2D)) and eating disorders (Atalayer et al., 2013

In contrast, the protective effects of FGF21 on ROS levels were significantly diminished in Slc25a39 CKO mice (Fig