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National guidelines suggest a fecal immunochemical test (FIT) can be used as the primary noninvasive screening modality for early-stage colorectal cancer, but a significant proportion of patients still receive a more expensive alternative test called Cologuard. Data used for national screening guidelines has shown no difference between the two tests at detecting adenoma versus colorectal malignancy. These results align with previous studies out of Japan and the Netherlands examining FIT as an appropriate screening modality that is more cost effective than other types of noninvasive colorectal screening tests. Rao, PK et al

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Stromal cells, including adipocytes, cancer-associated fibroblasts, and tumour-associated macrophages (TAMs), play an integral role in developing resistance to conventional treatment via various pathways

These improvements were comparable to those observed with common antidepressant drugs