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6 Persistence Data Patients who start KESIMPTA, stay on KESIMPTA Persistence and adherence with KESIMPTA and other first-line options 13-15 Persistence was defined as the time in months from the index date until treatment discontinuation

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Additionally, M2-type macrophages can be converted into M1-type macrophages when induced by iron nanoparticles ( 8.2 Ferroptosis exacerbates central inflammation Neuroinflammation is primarily initiated by astrocytes and microglia in response to factors such as injury, infection, exposure to toxins, or autoimmune reactions