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Preclinical studies suggest ALA may help defend neurons against oxidative stress, support synaptic function, and maintain healthy levels of glutathione, a critical antioxidant in brain cells.12 25 Importantly, ALA can cross the blood-brain barrier, making it a promising candidate for addressing conditions where oxidative stress or mitochondrial dysfunction play a role

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doi: 10.3389/fendo.2025.1568059 Received 28 January 2025 Accepted 10 April 2025 Published 30 April 2025 Volume 16 - 2025 Edited by Joao Dts Anselmo, Hospital do Divino Esprito Santo, Portugal Reviewed by Lucile Butruille, Musum National dHistoire Naturelle, France Updates Copyright 2025 Khudair, Khudair, Niinuma, Habib and Butler