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As these findings demonstrate, the increased risk of lung cancer observed in some studies was associated with extremely high doses of vitamin B12 approximately 23 times the recommended daily intake of 2.4 micrograms

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The folate-cobalamin interaction is pivotal for normal synthesis of purines and pyrimidines and the transfer of the methyl group to cobalamin is essential for the adequate supply of tetrahydrofolate, the substrate for metabolic steps that require folate

Once a multiple-dose vial is punctured, it should be assigned a "beyond-use" date