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Methods To evaluate clinical response associated with the SC and SL administration of apomorphine, we used the PK/PD model relating the circulating apomorphine concentrations to the changes in the Unified Parkinsons Disease Rating Scale (UPDRS) motor scores (UPDRS Part III), a standardly used rating scale in Parkinsons disease clinical trials [20]

In preclinical cell-based models, hCG is used to interrogate Leydig cell responsiveness, CYP enzyme induction kinetics, and receptor desensitisation and internalisation dynamics

doi:10.1111/j.1532-950x.2003.00515.x Pickart L, Margolina A

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