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Chronic stress signals, including hyperglycaemia, inflammation, neurohormonal activation, and mechanical overload, promote the activation of cardiac fibroblasts and the accumulation of extracellular matrix within the myocardium

Zoloft (sertraline) belongs to a class of medications known as selective serotonin reuptake inhibitors (SSRIs) which commonly treat mental health conditions like depression, anxiety disorder, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD)

Excitatory transmission is mainly mediated by cation-permeable ion channels, particularly glutamatergic receptors (AMPA, NMDA, kainate) and nicotinic acetylcholine receptors (nAChRs)