As the pens are multi-dose, you can reuse the pen for a month, but use a new needle each time
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Engagement of -glucans with Dectin-1 triggers tyrosine phosphorylation of an immunoreceptor tyrosine activation (ITAM)-like motif, which in turn recruits and activates the Syk tyrosine kinase, leading to activation of both NF-B and MAPKs through a signaling pathway mediated by Card9 and Raf (9, 1214)
