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this includes chlorambucil (adduct formation through nucleophilic substitution of the atom of chlorine [118]), cyclophosphamide (acrolein is one its main metabolites conjugating to GSH and becoming significantly less cytotoxic than the parent compound [119]), mitomycin C (forming mono- and bis-conjugates with GSH to be detoxified [120]), and various tyrosine kinases inhibitors (such as axitinib and sunitinib [121])

Animal reproduction studies with semaglutide have shown embryofetal toxicity, including structural abnormalities, at exposures below those expected at therapeutic doses in humans

Marked poikilocytosis is also noted with the presence of distorted red blood cells, irregularly contracted red blood cells, and red blood cells with apparently uneven distribution of the hemoglobin inside them (hemighosts)

E-mail address: mroaBpasteur.fr neal mast cells (6)