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True allergy to hydroxocobalamin is rare but real, so a brief history matters

All animals were maintained at SPF animal care facility of Zhongshan Hospital, Fudan University according to the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals, and the experimental protocols were approved by the Animal Care and Use Committee of Zhongshan Hospital, Fudan University

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The Hp1/2 proteins form different oligomers, such that a dimeric Hp11 molecule can bind two haemoglobin dimers, while the polymeric Hp21 and Hp 22 molecules have the capacity to bind greater numbers of haemoglobin dimers (Morton et al., 2006)