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doi: 10.1007/s11920-022-01369-6 36 MaNZhangJReiterRJMaX

After significant weight loss, patients commonly develop: Loose abdominal skin Stretch marks Lower abdominal overhang Muscle separation (diastasis recti) Persistent skin laxity No medication can tighten stretched abdominal skin or repair separated abdominal muscles

Spontaneous bilateral BGH occurs rarely, with only 60 instances having been reported in the literature [3]

Mechanistically, GLP1RAs improve cardiac function by enhancing contractility and reducing myocardial injury 14,15,16 , exert vasodilatory and endothelial-protective effects, and display anti-inflammatory and anti-fibrotic actions that may limit adverse remodeling in heart failure (HF) 17