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These compounds not only promote bone formation by upregulating the expression of RANKL but also inhibit bone resorption by activating the PI3K/AKT signaling pathway, thereby improving bone density and quality [143]

have shown that transgenic mice lacking the 2 subunit of AMPK, an important cellular fuel gauge, also lack GE neurons in ARC [79]

The induction of ferroptosis not only suppresses tumour growth but also enhances the efficacy of immunotherapeutic responses and mitigates resistance to existing cancer therapies

GLP-1RA therapy was associated with reductions in total cholesterol, low-density lipoprotein cholesterol and triglyceride levels compared with placebo or other hypoglycaemic agents