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These medications work by mimicking the action of the naturally occurring incretin hormone GLP-1, which is released from the intestine in response to food intake
You may benefit from a longer initial treatment course, a more gradual taper, or a commitment to maintenance dosing rather than complete discontinuation
Scientists found that GLP-1 receptor mRNA levels in the nucleus tractus solitarius (NTS) dropped after 1-2 weeks of treatment, matching when the drug started becoming less effective [24]
Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): data from randomized controlled trials
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