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Ondanks de korte plasma-halfwaardetijd persisteren de downstream biologische effecten in weefsel aanzienlijk langer, consistent met een signaalcascade in plaats van directe dosis-respons-activiteit

Infrequent bowel movements, fewer than three times a week Hard, dry stools that are difficult to pass Feeling bloated or full in your stomach Straining during bowel movements Abdominal discomfort or cramps If you notice these symptoms after starting gabapentin, it could be related to the medication

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The NHS Digital Weight Management Programme typically requires a BMI 30 kg/m (or 27.5 kg/m for certain ethnic groups) plus additional risk factors such as diabetes or hypertension