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however, pericentral zonation of liver damage occurred despite CYP-inhibition, suggesting that while CYPs do indeed detoxify OTA, other pericentrally located enzymes, which remain to be identified, metabolically activate OTA

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However, approval is conditional: adolescents must have severe obesity (BMI 35 or 95th percentile for age) and documented cardiovascular or metabolic complications such as type 2 diabetes, hypertension, or sleep apnea