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[5] Sustained NO Production - L-citrulline creates a longer-lasting elevation of plasma arginine levels compared to direct L-arginine supplementation, providing extended NO production benefits

GSH participates in thiol-disulfide exchange through a reversible reaction catalyzed by thiol-transferases as shown below, where Protein-SSG is a mixed disulfide and Protein-SH is reduced protein: The thiol-disulfide equilibrium is determined by the redox state of the cell, which is based on GSH and GSSG concentrations

Finally, achieving lower HbA1c levels with molecules that do not induce hypoglycemia may be associated with a reduced need for intensification and a lower risk of therapeutic inertia