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According to the authors of a 2017 meta-analysis 9 , we also need more welldesigned, randomised, placebocontrolled trials of LCarnitine for cognition enhancement in cognitively healthy people, with large samples and relatively longterm followup

554 Astrocyte pathology is a fundamental, if not leading, factor in neuronal death: astrocytes in ALS lose their capability to sustain neurones, to clear glutamate and they some aberrant astrocytic forms are generated, which may cause direct damage