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Unlike the combinatorial therapy of G-protein-coupled receptor-based peptide dual agonists, such as GLP-1/glucagon, these peptidyl nuclear hormone conjugates require additional consideration for differential pharmacodynamics where time action for clearance of each activity is inherently dissimilar

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[6] [15] Gallbladder disease, including cholelithiasis and cholecystitis, occurs more frequently with rapid weight loss

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