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While Metformin is typically the first-line treatment, Jardiance is a newer option offering added heart and kidney protection

S1a, b and Table S1)

Those with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 shouldnt use these drugs

The committee acknowledged the more recent indication that was approved for semaglutide (Wegovy) was to reduce the risk of non-fatal MI in adults with established CV disease and BMI equal to or greater than 27 kg/m 2 , but noted that the resubmission was submitted under the indication for weight management with a focus on patients with a history of CVD as per the sponsors decision