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Chronic inflammation is a root cause in the progression of many chronic illnessesfrom neurodegenerative diseases like Alzheimers and Parkinsons, to autoimmune conditions like psoriasis, and metabolic syndromes like diabetes and obesity

Studies have suggested that increased susceptibility to KBD in selenium-deficient populations might result from a reduced antioxidant protection associated with polymorphisms in GPX genes (60, 61), but polymorphisms in other genes have also been implicated (62)

Several forms of GCE have been characterized with the neonatal phenotype being the most common

Changes in body fat were also related to the changes in some serum indicators (blood glucose, triglycerides, LDL, HDL, and total cholesterol), which are clinically used to assess glucose lipid metabolism [26]