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report right upper quadrant pain to your GP or trial clinician Diabetic retinopathy worsening: Seek urgent ophthalmic review if you experience sudden changes in vision Hypoglycaemia: More relevant when retatrutide is used alongside insulin or sulphonylureas Injection site reactions: Persistent lumps, pain, or skin changes at injection sites should be assessed by a clinician When to seek help: Call 999 for severe chest pain, difficulty breathing, signs of severe dehydration (collapse, confusion), or suspected anaphylaxis Contact NHS 111 or your GP for persistent vomiting or diarrhoea, suspected pancreatitis, or any new or worsening symptoms that concern you There is currently no official MHRA safety profile for retatrutide, as it remains unlicensed

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Use 2-3 times weekly

This includes SSRI antidepressants (such as fluoxetine, sertraline, citalopram, etc.), SNRIs (like venlafaxine or duloxetine), tricyclic antidepressants (e.g