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Molecular docking with jr PPO1 and the five mutants Molecular docking was performed using AutoDock Vina 66 to identify binding poses of monophenolic (tyramine and L -tyrosine) and diphenolic substrates (dopamine and L -DOPA) within the active site of jr PPO1-wt and the five mutants in order to structurally analyse substrate binding and to identify differences between the wildtype and the mutants

Mice received water and diet (CRF-1

The technique was developed in 1960s, with the first specialized SANS diffractometers being developed at the Jlich research center in Germany in the early 1970s (Jacrot, 1976)

The diagnosis is made with upper endoscopy and barium esophagogram, to assess the morphology of HH