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Highlights: Retatrutide targets GLP-1, GIP, and glucagon to reduce appetite, regulate fat storage, and manage blood sugar A trial showed a higher dose of Retatrutide produced 20% more weight loss over 48 weeks Common side effects include diarrhea, nausea, and vomiting , with at least one death reported Trusted Source Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial Go to source)