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In a randomized, placebo-controlled trial in 1,374 participants who had colonoscopic removal of at least one colorectal adenoma (the Selenium and Celecoxib trial), selenium supplementation (200 g/day with selenized yeast) for a median of 33 months had no effect on colorectal adenoma recurrence (88)

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Binding to mitochondrial proteins, especially in the context of glutathione (GSH) depletion, is critical because it disrupts the natural antioxidant functions of mitochondria and alters the ATP-synthase -subunit, impairing ATP production [93]

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