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For weight management, lack of at least 5% weight loss by 12 weeks at the maintenance dose warrants discussion about alternative strategies or dose optimization

For those who choose to discontinue the medication, preparation and clear expectations matter

Other dietary approaches may stimulate GLP-1 secretion more reliably, including consumption of protein-rich meals, dietary fiber (particularly viscous fibers), and certain fermentable carbohydrates that promote short-chain fatty acid production in the colon

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