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Therefore, to investigate the influence of GST enzyme activity on busulfan metabolism, the empirical model developed was used as a base, with a dedicated compartment incorporated to dynamically quantify the relative amount of GSH available over time, based on theoretical mechanisms, as reported by Langenhorst et al

For private prescription, while there might be no requirement to await NICE approval, the actual stock of the treatment will need to be manufactured, imported and distributed through the UK supply chain before pharmacies can dispense it, says Ana Caroline Gonvalves, superintendent pharmacist at Pharmica

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