6 Morin hydrate as an adjuvant to overcome cisplatin resistance and toxicity in liver cancer Cisplatin resistance in liver cancer is driven by PARP1-mediated autophagy via the HMGB1 pathway
However, some find absorption issues persist due to digestive factors or medication use
Concurrently, insulin resistance, chronic inflammation, and obesity contribute to ROS overproduction, while the activity of antioxidant enzymes (such as superoxide dismutase and glutathione peroxidase) are significantly reduced ( In PCOS, excessive ROS inflict damage on oocytes and granulosa cells, disrupt the follicular microenvironment, and impair follicular development and ovulation ( e.g ., CYP17) in ovarian theca cells, exacerbating hyperandrogenemia ( e.g ., vitamin C, vitamin E, N-acetylcysteine) may mitigate oxidative damage, improve insulin sensitivity, and restore ovarian function by neutralizing ROS ( 3.2 Autophagy Autophagy is a fundamental cellular process responsible for degrading and recycling damaged organelles and proteins, playing a critical role in maintaining cellular homeostasis
doi: 10.1038/jid.2014.273 9 CrinerGJCelliBRBrightlingCEAgustiAPapiASinghDet al
