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What we know from TRIUMPH-4 (blood pressure through 68 weeks): Systolic BP: -14.0 mmHg (12mg dose, efficacy estimand) Diastolic BP: -4.3 mmHg average reduction These reductions persisted even as weight loss plateaued in the final weeks, suggesting blood pressure benefits may be partially independent of weight possibly due to direct GLP-1 and glucagon receptor effects on vascular function

Edgar, L

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By targeting NNMTan enzyme highly expressed in adipose tissue and linked to insulin resistancethis compound allows researchers to explore how shifting cellular metabolism away from fat storage toward energy utilization can impact systemic health