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One region is termed as G-site, which is hydrophilic in nature and binds the physiological substrate GSH, and another region is the H-site, which assists in binding of electrophilic substrates by providing a hydrophobic environment (Frova, 2003)

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Excessive iron limitation may impair normal hematopoiesis and neurological development, while inadequate dosing fails to prevent pathogen-induced ferroptosis