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This meta-analysis of all CVOTs conducted with oral and parenteral semaglutide to date revealed that the use of semaglutide as a molecule resulted in a significant 21% reduction in MACE, which was driven by reduction in CV death (HR 0.79, 95% CI 0.610.90)

The present review thus focuses on the role of GPX4 in the myeloid lineage, describing how increase in GPX4 expression can impact on myeloid cell homeostasis and transformation and whether GPX4 inhibition could represent an attractive strategy to treat AML patients

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