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334 Endothelial cells In addition to enhancing tumor invasion and metastasis via tumor cell lactate autocrine as mentioned above, paracrine secretion of lactate can directly modulate endothelial cell phenotype, thereby altering tumor vascular morphogenesis and perfusion
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[4] In contrast, methionine limitation in the diet decreased insulin resistance in rodents and promoted adipose tissue lipolysis and fatty acid oxidation
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