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doi: 10.1111/j.1365-4632.2010.04381.x 61 KimCCBerryEGMarchettiMASwetterSMLimGGrossmanDet al

While effective in oncology, these agents can lead to long-term adverse health outcomes for female cancer patients, including endocrine disruption, amenorrhea, premature ovarian insufficiency and infertility (Green et al, 2009a

Not replacing pressure-lowering treatments as primary therapy

Given the small sample size, absence of a comparator group, lack of formal event adjudication, and limited statistical power, no conclusions regarding cardiovascular benefit or harm can be drawn