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This makes it safer than direct human growth hormone replacement for anti-aging purposes

MHRA and EMA recognise cholelithiasis and cholecystitis as adverse reactions to GLP-1 therapy requiring ongoing monitoring

While the decrease in HbA1c levels reached a plateau at 24 weeks, weight loss in the 2 studies was progressive without evidence of attenuation effect up to the end of follow-up at 36-48 weeks

Tirzepatide was non-inferior and statistically superior on HbA1c reduction (up to 2.30% at 15 mg versus 1.86% for semaglutide) and produced substantially greater weight loss (roughly 11 to 12 kg at the top dose versus about 6 kg)