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Group 2 received oral clonazepam tablets (0.5 mg once or twice daily, PO) for 8 weeks

In contrast, while the dose-response relationship between -cell responsiveness to glucose (expressed as the slope of the linear relation between insulin secretion rate and the glucose concentration) and GLP-1 levels in circulation is partially impaired a phenomenon referred as GLP-1 resistance (62) a therapeutic infusion of GLP-1 at a pharmacological dose can restore -cell insulin secretion responsiveness to glucose levels comparable to those observed in nondiabetic individuals (62)

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The scientific evidence on their effectiveness is still evolving, and they are not a substitute for long-term healthy habits