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However, the application of CeO x -based nanozyme to suppress ROS levels still faces the major challenge that Ce (III) would rapidly react with ROS to oxidize Ce (IV) in the pathological microenvironment, disrupting the original redox cycle to restrict its catalytic activity, so that it is essential to introduce an extra stabilizer to maintain the nanozyme function 18

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The corresponding cysteine in ATPS of the diatom Phaeodactylum tricornutum has been described to be sensitive to oxidation by H 2 O 2 , as well as several other less conserved cysteine residues (Rosenwasser et al., 2014)

You do not want to be taking antioxidants during that time