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caution and clinical monitoring are appropriate People taking insulin or insulin secretagogues (such as sulphonylureas), where the risk of hypoglycaemia may be increased, and dose adjustment of the concomitant agent may be needed Those with active or unstable diabetic retinopathy , given the potential for transient worsening with rapid glycaemic improvement People taking oral medicines with a narrow therapeutic index , where delayed gastric emptying could affect drug absorption Regarding medullary thyroid carcinoma (MTC) and Multiple Endocrine Neoplasia syndrome type 2 (MEN2): animal studies with GLP-1 receptor agonists have shown thyroid C-cell changes, and some regulatory authorities have issued precautionary warnings

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These symptoms often resolve quickly on their own