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10.1172/JCI43615 106
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The question, as always with resM, is whether the specific strain (RSB11) at the specific dose in the specific product produces clinically meaningful effects in humans
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At the ultrastructural level, irregular and immature elastin fibers and fibers devoid of microfibrils were observed. These findings suggested that both elastic fiber abnormalities and reduced collagen content contribute to the clinical features seen in patients with clEDS. There were no consistent electron microscopy (EM) findings in the ten patients in our cohort who had EM performed
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