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FIGURE 2 The dataset exhibited substantial multi-target activity, with 97 sequences (41.5%) demonstrating dual agonism for GCGR and GLP1R, 24 sequences (10.3%) for GCGR and GIPR, and 31 sequences (13.2%) for GLP1R and GIPR (Figure 2)

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Several randomized controlled trials and meta-analyses report that oral or enteral glutamine can reduce markers of intestinal permeability in acute or short-term settings, such as following intense exercise or during critical illness