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Experts who have studied the field are particularly concerned that some people are combining multiple peptides

Zepbound has only one active ingredient (tirzepatide)

Clinical considerations for discontinuation include but are not limited to pregnancy, adjudicationconfirmed pancreatitis, malignancy, a BMI of 18.5 kg/m 2 , treatment with bariatric surgery, or a systemic hypersensitivity reaction

185 Familial hemiplegic migraine Familial hemiplegic migraine FHM type 2, clinically manifested as migraine with aura, is linked to loss-of function mutations of the ATP1A2 gene encoding the astrocyte-specific 2 subunit of Na + /K + ATPase (NKA)