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In addition to the observed increase in mitochondrial fragmentation, the overexpression of FIS1 has also been demonstrated to result in mitochondrial dysfunction and an increase in autophagosome formation (Twig et al., 2008)

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2 Micale et al 2021 Around 10% of those with generalised joint hypermobility have accompanying physical and/or psychological symptoms , 3 and are therefore eligible for assessment for a diagnosis of a Heritable Connective Tissue Disorder like hypermobile EDS (hEDS), or a Hypermobility Spectrum Disorder

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