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Understanding these complications is crucial as it informs not only the management strategies but also underscores the importance of early intervention and comprehensive care

We know that not only can the brain be a target of the peripheral immune system, but also that the organ itself is home to a broad and diffuse immune system, present in the meningeal membranes, choroid plexus, cerebrospinal fluid and even directly in the brain parenchyma [49,50]

That fits neatly with the idea of weight loss as the real driver, because weight loss itself also plateaus beyond a certain dose