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Primarily, they found that increased carnosine levels may play an important role in antioxidant production, which can scavenge harmful substances such as reactive oxygen species (ROS) which are linked to cell damage and diseases such as cancer [25]

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Both types of reactions oxidize GSH to GSSG that can accumulate transiently in cultured rat astrocytes during treatments that cause oxidative stress (Arend et al

Table 1 Efficacy of DPP-4 inhibitors in the clinical phase III programmes with at least 52 weeks duration as add on therapy to metformin compared to sulfonylureas