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DOI: 10.1038/sj.ejcn.1602109

Future prospects Today, the available pharmacological arsenal includes approaches to emerging conditions such as peripheral arterial disease and neurodegenerative disorders, further reinforcing the role of metabolic diseases in the pathophysiology of various conditions that have a profound impact on both quality of life and life expectancy in the population.60 Advances in knowledge and biochemical engineering are paving the way for intervention at multiple levels in the prevention and treatment of various complications, while also promoting therapeutic individualisation

We aim to demonstrate how inadequate consideration of the typical trajectory of weight gain following antipsychotic initiation among susceptible patients, and associated timing of metformin introduction within trials assessing its efficacy, have led to inaccurate conclusions regarding its role within management algorithms