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In assessing college students non-medical use of prescription stimulants, a 2017 report found no cognitive improvement in learning or memory when using stimulants compared to a placebo

The mechanism of action involves activation of both GIP and GLP-1 receptors, which are naturally occurring incretin hormones that play important roles in glucose homeostasis and appetite regulation

A broader outcome that also included nonfatal heart attack and stroke likewise showed a lower rate (25.4% versus 33.8% ), but again this difference was not strong enough to confirm a clear benefit

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